Mesothelioma The "epidemic" Turkish

One of the more important studies on mesothelioma family is that reported by Roushdy-Hammady et al. in 2001 . These authors have studied for 2 years the inhabitants of two villages in Cappadocia in Turkey (Karain and tuzkoy) where nearly half of the villagers die of mesothelioma. This effect could be explained only partially by exposure to a carcinogenic mineral fiber of volcanic origin (erionite). Roushdy-Hammady et al. then began a genetic factor that could explain the importance of the effect observed in some homes (houses of death). By studying the pedigree of 526 individuals over 6 generations, they have found a predisposing factor to be autosomal dominant in these populations. According to their findings, over 50% of subjects with a parent diagnosed with mesothelioma in developed also.
This study was completed shortly after the study by Dogan et al. which found that the mutagenic mineral found in Turkey (erionite) was also found in California and Europe without being associated with such incidence of mesothelioma. However, analysis of erionite fragments derived from different continents by X-ray showed that the structure of this mineral was identical irrespective of geographic origin. Furthermore, analysis of 24 families from three villages (Karain, tuzkoy Sarihidir and old) revealed that the union of a story from a family marked by a high incidence of mesothelioma with no family history of disease leading to offspring with mesothelioma. In contrast, families at high risk of mesothelioma do not live in the villages concerned, and therefore not exposed to erionite, did not develop the disease