Thursday, March 4, 2010

Mesothelioma and enzyme polymorphisms


Another approach to the problem was based on finding an enzyme polymorphisms may explain individual susceptibility. Are numerous publications on the subject and may tend to contradict themselves.
Thus, Hirvonen et al. reported the results of a study finding an increased risk of mesothelioma in 145 subjects exposed to asbestos and having an enzymatic activity glutathione S-transferase μ (GSTμ) null (OR = 2.3, 95% = [ 1,1-4,7]), and higher still if no enzyme activity was associated with an activity N-acetyltransferase 2 (NAT2) slow acetylators (OR = 3.8, 95% CI = [1-14,3 ]).

A subsequent study confirmed the increased risk of mesothelioma in 80 patients with low exposure to asbestos and having an enzymatic activity GSTμ zero but contrary to the findings of the previous study, the risk was further increased if activity GSTμ zero s' associated with an activity N-acetyl transferase 2 rapid acetylators (OR = 2.14, CI 95% = [1,15-3,98]). An active low microsomal epoxide hydrolase was associated with an increased risk of mesothelioma (OR = 2.51, CI 95% = [1,11-5,68]) .

Stucker et al. [38] have not found an association between the diseases related to asbestos and isoforms GSTμ or t in 107 patients with asbestosis exposure.

It is therefore currently not possible to conclude an individual enzyme profile associated with an increased risk of mesothelioma.

No comments:

Post a Comment