Descriptions of familial cases of mesothelioma

Since Li et al. discussed a possible genetic contribution to mesothelioma in 1978 , more than 500 cases of mesothelioma family have been described in the literature but no studies have identified clear genetic factor. Among the most important descriptions, Bianchi et al. reported in the city of Trieste Montfalcone, 40 cases of mesothelioma family (seen in 19 families) of 610 mesotheliomas tested and developed, mostly in the context of domestic or occupational exposure to asbestos ( shipbuilding) . Dawson et al. reported 17 cases of mesothelioma family from 8 families whose members have been exposed to asbestos. Similarly, Risberg et al. described 5 relatives of first degree mesothelioma (father, 3 brothers and 1 sister), for the most exposed to asbestos (4 / 5). Finally, Picklesimer has recently reported the case of a man and his sister who developed both a concept without mesothelioma asbestosis exposure .
Only Bianchi et al. evaluated the proportion of familial cases among all mesotheliomas diagnosed: 40 of 610 familial cases analyzed mesothelioma, an observed proportion of familial mesothelioma of 6.5%.