An exhibition, sometimes short (one to two years) or longer can trigger the phenomenon that will lead twenty-twenty-five years before the onset of the disease.
When observing a patient, a pleural tumor, type of mesothelioma, the interrogation is to try to find if the patient has been exposed to asbestos. Mesotheliomas are usually localized. Sometimes, when the tumor is malignant, it may appear metastases.
Most often, these mesotheliomas are marked by a pleural effusion, which masks the underlying tumor. To make the diagnosis, we help each other often pleural biopsy needle. Sometimes a biopsy pleuroscopie (under anesthesia by inserting a small endoscope into the pleura) is needed to pinpoint the location of the tumor and to a levy at this level.
Treatment is primarily surgical, sometimes supplemented by chemotherapy and radiotherapy. The active research is ongoing to better understand the link between exposure to asbestos and the onset, years later, these pleural tumors.
Thursday, March 4, 2010
Advances in the treatment of mesothelioma
Mesothelioma, asbestos cancer, resistant to all current medical treatment. At Caen, a team of researchers developed innovative techniques to address them.
The cell mesothelioma, asbestos cancer, is a monstrosity of nature. She resists because of his own death - or apoptosis - in which every cell is normally scheduled. Apoptosis is "like falling leaves in autumn when day length decreases, explains Dr. Lawrence Poulain, a researcher in the unit "Biology and innovative therapies for patients with locally aggressive" (Bioticla) Regional Group of Study on Cancer (GRECAN), affiliated with the University of Caen Basse-Normandie. The health professional may be found at the parade this "immunity" of mesothelioma.
The cell mesothelioma, asbestos cancer, is a monstrosity of nature. She resists because of his own death - or apoptosis - in which every cell is normally scheduled. Apoptosis is "like falling leaves in autumn when day length decreases, explains Dr. Lawrence Poulain, a researcher in the unit "Biology and innovative therapies for patients with locally aggressive" (Bioticla) Regional Group of Study on Cancer (GRECAN), affiliated with the University of Caen Basse-Normandie. The health professional may be found at the parade this "immunity" of mesothelioma.
Mesothelioma more information
mesothelioma is a malignant tumor of mesothelial surfaces mainly affecting the pleura and less commonly the peritoneum and rarely the pericardium. Tobacco plays no role in the risk of developing mesothelioma.
The occurrence of this disease, sometimes referred to asbestos cancer, this fiber is the only recognized risk factor for cervical cancer, is not indicative of a minimum threshold of exposure and medical treatment has an impact limited to the life expectancy of patients, usually 12 to 18 months.
The first signs found on clinical examination are chest pain, often associated with breathlessness and recurrent pleural effusion, usually bleeding. The latency between first exposure and the development of mesothelioma is seldom less than 20 years, often around 30 to 40 years or more. It does not seem to exist a threshold value of exposure in relation to risk of onset.
He described cases of pleural mesothelioma occurring in the family environment close to the workers exposed to asbestos, subjects were exposed due to contamination of residential premises or during maintenance of dusty clothes.
The occurrence of this disease, sometimes referred to asbestos cancer, this fiber is the only recognized risk factor for cervical cancer, is not indicative of a minimum threshold of exposure and medical treatment has an impact limited to the life expectancy of patients, usually 12 to 18 months.
The first signs found on clinical examination are chest pain, often associated with breathlessness and recurrent pleural effusion, usually bleeding. The latency between first exposure and the development of mesothelioma is seldom less than 20 years, often around 30 to 40 years or more. It does not seem to exist a threshold value of exposure in relation to risk of onset.
He described cases of pleural mesothelioma occurring in the family environment close to the workers exposed to asbestos, subjects were exposed due to contamination of residential premises or during maintenance of dusty clothes.
Sign of mesothelioma
The main sign of mesothelioma is the effusion of fluid in the pleura, which causes pain and discomfort in breathing, this is called a pleural effusion or "pleurisy".
This symptom may nevertheless be found in other diseases such as lung infections. Knowing that the effects of asbestos may not manifest itself until several years later, the most important thing is to make a review when the lung is thought to have been exposed to asbestos, even long ago and for a short period
If you have or develop symptoms, consult your doctor
This symptom may nevertheless be found in other diseases such as lung infections. Knowing that the effects of asbestos may not manifest itself until several years later, the most important thing is to make a review when the lung is thought to have been exposed to asbestos, even long ago and for a short period
If you have or develop symptoms, consult your doctor
Pleural cancer (mesothelioma)
The pleura is a double flexible casing surrounding the lungs with a sheet on the side of the lungs, and a sheet on the side of the chest. During inspiration, the thoracic cavity enlarges. Thanks to the pleura, which acts as an interface, the lung also s'expand.
The pleura may be cancerous. In 50 to 70% of cases the cause is exposure to asbestos, often occupational (insulation, textiles, construction, filters). Tobacco is not an issue. Asbestos is a product completely natural. It is a silicate of iron, magnesium and calcium (a mineral so) that forms the flexible fibers, rot and fire resistant. It is found in large quantities, especially since Canada is the world's largest producer.
The most common uses are thermal insulation and soundproofing for fibers "amphibole" and the manufacture of cement for fiber "chrysotile." Inhaled, amphibole fibers strongly promote cancer of the pleura. However, this risk is disputed by producer countries for chrysotile fiber cement. On this point, the opinion of European experts is in favor of a probable risk (difficult to quantify because the incidence of mesothelioma is comparatively unimportant).
For the record, exposure to asbestos fibers can cause three types of diseases: pulmonary fibrosis (asbestosis), leading to progressive respiratory failure, lung cancer (but we know that smoking is a risk factor even larger than l 'asbestos) and cancer of the pleura or "mesothelioma.
Exposure to asbestos can sometimes be very brief and very old (up to 40 years). The number of cases of cancer of the pleura increases by 25% every three years!
The pleura may be cancerous. In 50 to 70% of cases the cause is exposure to asbestos, often occupational (insulation, textiles, construction, filters). Tobacco is not an issue. Asbestos is a product completely natural. It is a silicate of iron, magnesium and calcium (a mineral so) that forms the flexible fibers, rot and fire resistant. It is found in large quantities, especially since Canada is the world's largest producer.
The most common uses are thermal insulation and soundproofing for fibers "amphibole" and the manufacture of cement for fiber "chrysotile." Inhaled, amphibole fibers strongly promote cancer of the pleura. However, this risk is disputed by producer countries for chrysotile fiber cement. On this point, the opinion of European experts is in favor of a probable risk (difficult to quantify because the incidence of mesothelioma is comparatively unimportant).
For the record, exposure to asbestos fibers can cause three types of diseases: pulmonary fibrosis (asbestosis), leading to progressive respiratory failure, lung cancer (but we know that smoking is a risk factor even larger than l 'asbestos) and cancer of the pleura or "mesothelioma.
Exposure to asbestos can sometimes be very brief and very old (up to 40 years). The number of cases of cancer of the pleura increases by 25% every three years!
Mesithelioma : To help you
To help you
Living with mesothelioma is not always an easy thing ...
THE CONTEXT
You and entourage have many problems and challenges. Your life will be made easier if you are properly informed. Doctors and other members of the medical team can direct you to agencies for assistance so you can find a moral, social and possibly financial.
Living with mesothelioma is not always an easy thing ...
THE CONTEXT
You and entourage have many problems and challenges. Your life will be made easier if you are properly informed. Doctors and other members of the medical team can direct you to agencies for assistance so you can find a moral, social and possibly financial.
Mesothelioma The future
A new marker
THE CONTEXT
For a long time, methods of early detection in case of exposure to asbestos, are sought because of the high risk of cancer after such exposure.
Osteopontin
A clinical study showed that the presence of serum levels of osteopontin, a glycoprotein involved in cell-matrix interactions, is an effective screening tool for pleural mesothelioma. In an essay published recently, the sensitivity of the method was confirmed. High levels of osteopontin were found in mesothelioma cases, whatever their histological type and including the forms at an early stage.
PRACTICE ...
Measurement of serum levels of osteopontin in patients with a history of exposure to asbestos could become a sensitive and specific tool for early detection of disease.
THE CONTEXT
For a long time, methods of early detection in case of exposure to asbestos, are sought because of the high risk of cancer after such exposure.
Osteopontin
A clinical study showed that the presence of serum levels of osteopontin, a glycoprotein involved in cell-matrix interactions, is an effective screening tool for pleural mesothelioma. In an essay published recently, the sensitivity of the method was confirmed. High levels of osteopontin were found in mesothelioma cases, whatever their histological type and including the forms at an early stage.
PRACTICE ...
Measurement of serum levels of osteopontin in patients with a history of exposure to asbestos could become a sensitive and specific tool for early detection of disease.
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